Child maltreatment not only leads to epigenetic changes, but also increases the risk of related behavioral deficits and mental disorders. These issues presumably are most closely associated with epigenetic changes in the brain, but epigenetic changes in peripheral tissues like blood are often examined instead, due to their accessibility. As such, the reliability of using the peripheral epigenome as a proxy for that of the brain is imperative. Previously, our lab has found aberrant methylation at the Brain-derived neurotrophic factor gene (...) in the prefrontal cortex of rats following aversive caregiving. The current study examined whether aversive caregiving alters Bdnf DNA methylation in the blood compared to the prefrontal cortex. It was revealed that DNA methylation associated with adversity increased in both tissues, but this methylation was not correlated between tissues. These findings indicate that group trends in Bdnf methylation between blood and the brain are comparable, but variation exists among individual subjects. (shrink)

In October 1984, Bruno Huisman stated with regards to Jean Cavaillès, ‘Let us be honest, or at least realistic: today, one can be a professor of philosophy without ever having read a single line of Cavaillès. Often invoked, sometimes quoted, the oeuvre of Cavaillès is little attended for itself’ (Huisman 1984). As for Albert Lautman, it would seem that the situation is even more extreme. In 1994, the publisher Hermann, under the impetus of Bruno Huisman and George Canguilhem, collected almost (...) the totality of the Jean Cavaillès papers in one volume (Oeuvres complètes de philosophie des sciences (Cavaillès 1994)). But, the Essai sur l’unité des mathématiques et divers écrits (Lautman 1977), published by the Union générale d’Éditions in 1977, had all but disappeared by the early 1980s and yet was never republished! This will remain one of the great indignities of French publishing, for as Jean Petitot rightly affirms: ‘Regarded as too speculative, in spite of his exceptional mathematical scholarship and his close connection with Hilbertian axiomatic structuralism, his mathematical philosophy has, until now, been devoid of any particular attention …. We would like to state clearly from the start, Albert Lautman represents, in our view, without exaggeration, one of the most inspired philosophers of this century’ (Petitot 1987, 79-80). (shrink)

Newton's conception of time has had a profound influence upon science, particularly psychology. Five characteristics of explanation have devolved from Newton's temporal framework: objectivity, continuity, linearity, universality, and reductivity. These characteristics are outlined in the present essay and shown to be central to psychological theories and methods. Indeed, Newton's temporal framework is so central that it often goes unexamined in psychology. Examination is important, however, because recent critics of Newton's framework - including both scientists and philosophers - have questioned its (...) validity and usefulness. (shrink)

In addition to facing the known competitors in the formal economy, entrepreneurs must also be concerned with rivalry emanating from the informal economy. The informal economy is characterized by actions outside the normal scope of commerce, such as unsanctioned payments and gift-giving, as means of influencing competition. Scholars and policy makers alike have an interest in mitigating the impacts of such informal activity in that it might present an obstacle for legitimate commerce. Received theory suggests that country institutions can enable (...) and constrain productive activity, and, in doing so, influence competitive obstacles in a country. Leveraging 13,670 responses from entrepreneurs distributed across 59 countries, we provide evidence that two particular types of enabling institutions, countries’ property rights regulations and cooperative actions, are useful for lowering the obstacles presented by informal activity. We also find evidence that two constraining institutions, economic and financial regulations lead to more obstacles presented by informal activity. We describe implications for entrepreneurs, policy makers, and future researchers stemming from these findings. (shrink)

This first article is intended as a brief introduction to the general philosophical assumptions of Newton: namely, his mathematicism, empiricism, positivism, reductionism, and dualism. These five "isms" provide an important background to the main articles that are also briefly described.

Merleau-Ponty had projected a work of considerable dimensions, according to Lefort, which was to have borne the title now given to this posthumous volume. Though the chapters he had actually written out and the notes de travail selected by Lefort for this edition seem to be only introductory parts and suggestions of the larger work, they are already considerable in richness, depth and difficulty. Here we find Merleau-Ponty returning to the problems of his earlier works, showing why the problems posed (...) in the Phenomenology of Perception were "insoluble"; examining in ever greater depth the thought of Descartes, Leibniz, Kant, Hegel, Husserl, Heidegger and Sartre; uncovering the naiveté of scientific thinking and the false sophistication of reflective, dialectical and intuitionistic philosophies. He has moved well beyond phenomenology in the strict sense, toward his own interrogation ontologique and a theory of logic. Lefort has done an extraordinary and exemplary job of organizing, editing and annotating the manuscripts. —A. B. D. and C. D. (shrink)

Early versions of satellite and radiosonde datasets suggested that the tropical surface had warmed more than the troposphere, while climate models consistently showed tropospheric amplification of surface warming in response to human-caused increases in greenhouse gases. We revisit such comparisons here using new observational estimates of surface and tropospheric temperature changes. We find that there is no longer a serious discrepancy between modeled and observed trends in the tropics. Our results contradict a recent claim that all simulated temperature trends in (...) the tropical troposphere are inconsistent with observations. This claim was based on the use of older radiosonde and satellite datasets and on two methodological errors: the neglect of observational trend uncertainties introduced by interannual climate variability and application of an inappropriate statistical “consistency test”.This emerging reconciliation of models and observations has two primary explanations. First, because of changes in the treatment of buoy and satellite information, new surface temperature datasets yield slightly reduced tropical warming relative to earlier versions. Second, recently developed satellite and radiosonde datasets now show larger warming of the tropical lower troposphere. In the case of a new satellite dataset from remote sensing systems, enhancedRSS warming is due to an improved procedure of adjusting for inter-satellite biases. When the RSS-derived tropospheric temperature trend is compared with four different observed estimates of surface temperature change, the surface warming is invariably amplified in the tropical troposphere, consistent with model results. Even if we use data from a second satellite dataset with smaller tropospheric warming than in remote sensing systems RSS, observed tropical lapse rates are not significantly different from those in all model simulations.Our results contradict a recent claim that all simulated temperature trends in the tropical troposphere and in tropical lapse rates are inconsistent with observations. This claim was based on the use of older radiosonde and satellite datasets and on two methodological errors: the neglect of observational trend uncertainties introduced by interannual climate variability and application of an inappropriate statistical “consistency test”. (shrink)

The two epigraphical monuments which have preserved parts of the treaties of alliance between Athens, on the one hand, and Rhegion and Leontinoi, respectively, on the other, must be studied together, for both treaties had their old preambles erased in 433/2 and their validity reaffirmed as of that year. The new preambles, both dating from the same day, were inscribed in the erasures and juxtaposed, somewhat awkwardly, before the body of the old texts thatstill remained.

A reprint of the book published in 1942, with the addition of an appendix and a new preface. Beginning with the concrete and conceptual aspects of the person and showing how the principles of logic are embodied in human experience, the author describes the ontological and logical connections between the world, man and God.--A. B. D.

A scholarly, clearly written interpretation of the Oresteia, interweaving the aesthetic, moral, political and cosmic elements in the drama. The author gives a valuable assessment of Aeschylus' reaction to the then current ideas of Plato and Aristotle. In an excellent chapter on the meanings of catharsis, he shows how Aeschylus interpreted Aristotle's theory of tragedy.--A. B. D.

Edith Stein was Husserl's student and private secretary. This study of empathy was originally her doctoral dissertation. After a reduction to pure consciousness, she describes the essence of empathy as a kind of perception sui generis, both like and unlike other acts of consciousness. Different theories of experiencing the other are briefly evaluated. The second part of the book is devoted to the role of empathy in the constitution of the psycho-physical individual and, ultimately, of the person. Written in short, (...) numbered paragraphs, the analysis tends to be jerky and without direction. But there is a sustained description of the living body, antedating Merleau-Ponty's corps vécu by thirty years. The translation seems too literal, and typographical errors abound.—A. B. D. (shrink)

Summary A study of the metallurgy and manufacturing techniques of a group of eight astrolabes using non-destructive methods has produced the earliest evidence for systematic use of high-zinc brass. To produce this alloy, the brass industry supplying the Lahore instrument makers must have co-melted metallic copper and zinc. This brass-making technology was previously believed to have been developed on an industrial scale in the nineteenth century in Europe. This work hypothesizes that this technology was used in Lahore on an industrial (...) scale as early as ad 1601. In addition, this work hypothesizes that the α + β brass alloy was used specifically for its ease in manufacturing the thin sheet brass required for astrolabe-component manufacture. (shrink)

This second, more cohesive volume of Schutz's papers goes beyond the critical and inconclusive work of Volume I, to advance, not quite a theory, but certain postulates for the interpretation of social phenomena. Schutz contends that the social scientist, normally an impartial observer, must also assume the standpoint of the subject: he must ask what is the meaning and rationality of social action for the actor himself. From such a bi-polar perspective Schutz describes the situations of "The Stranger," "The Homecomer," (...) and "The Well-Informed Citizen." In the longest paper he analyzes the meaning of equality both for those who are and for those who are not equal. These papers are perceptive—the best in the volume.—A. B. D. (shrink)

Aristotle's rejection of the Platonic ideas robbed him of Plato's unity of Being and Value as well. By an extensive, clear interpretation and analysis of the whole Aristotelian corpus, Oates shows that Aristotle lacks a coherent theory of value. While considerations of value unavoidably occur in the Metaphysics, just as ontological ones do in the Ethics, nowhere in Aristotle is there a unification of axiology and ontology. For this reason, Oates argues, the Nicomachean Ethics fails to be a theory of (...) moral good. The book is a temperate, perhaps non-controversial critique of Aristotle, and its polished, easy style makes it a pleasure to read.—A. B. D. (shrink)

A far less exhaustive work than Richardson's scholarly tome, but more focused than Vycinas' ventriloquial interpretation, Guilead's book concentrates on the theme of freedom in Sein und Zeit and in Heidegger's later works. The author is in full control of Heidegger's terminology and he succinctly reports how Heidegger uncovers and destroys the subjectivism of modern philosophy, as represented by Descartes, Leibniz, Kant, Nietzsche, and Marx. Guilead contends that the germ of the "Kehre" was already present in Sein und Seit [[sic]]. (...) Heidegger's later thought shows that man is a cosmic being, a relation to Being, and his freedom can not be rooted in subjectivity but in the realization of his authentic cosmic being, in his "habitation," "dwelling," and "building." The author finds two problems in Heidegger's philosophy: a lack of real otherness in beings, and a danger of humanizing Being. But are they not one problem?—A. B. D. (shrink)

Daniel Lagache has said that the psychoanalytical experience is a moral one. It is, in Mme. Amado's words, "the drama of a subject, discovering his radical truth." The task of psychoanalysis is the demystification of the narcissistic, alienated subject who lives in a primary or primitive moment of subjectivity. The moment of cure is the recognition of the other, and simultaneously, a discovery of oneself--intersubjectivity. Mme. Amado gives an excellent phenomenology of alienation, seeing its presence both in mental disorders and (...) normal behavior.--A. B. D. (shrink)

This is a compact, comparative analysis of Western and Chinese thought according to distinctive styles of thought and attitudes toward the world and what can be known of it. The model of Western Philosophy is presented as an abstract whole beyond experience—the Kantian ideal; the model of Chinese thought is a concrete whole found in experience. Chinese thought, as amply represented by passages from Confucius, Mencius and others, always has a feeling for the concrete, for a particular fact intuitively suggesting (...) a universal law; and it always has a predilection for paradox. The author thinks that abstract Western thought is still under the sway of Kant's concepts and forms of judgment, even in its current tendency toward the concrete.—A. B. D. (shrink)

This is a standard selection of readings taken from Aristotle, Descartes, Hume, Kant, and James. The introduction and commentary are not sufficient to distinguish this anthology from similar introductions—D. J. B.

We agree that treating rules and similarity as dichotomous opposites is unproductive. However, describing all categorization operations as a continuum of varied similarity process obscures a multidimensional contrast. We describe two processes, instantiated rules and abstract analogy, both of which have aspects of rules and similarity, and question whether they can be compared informatively as points on a continuum.

This collection of Professor S. Sastri's work indicates the depth of his contribution to Indian philosophy. The reader will find his development of Bradley's Idealism in the light of the Advaita tradition to be of special philosophic interest.--D. P. B.

Father Dougherty's textbook is relatively indistinguishable from a host of similar Thomistic manuals. There are the invariable definitions of being, substances, causality, etc., followed by the usual refutations of alien philosophies plus the inevitable series of pedagogical questions at the end of each chapter. It is curious that despite the continual fulminations of certain neo-Thomists against textbook Thomism, there appears a new harvest of such textbooks every year.—D. J. B.

A new and idiomatic translation of the most important questions in the Summa Theologica pertaining to the nature of the human soul and human knowledge.--D. P. B.